Soluble tumor necrosis factor alpha receptor type 1 in psoriasis patients treated with narrowband ultraviolet B.

Type:Uv phototherapy Time:2015-01-15 13:40:36

PURPOSE:

The purpose of this study was to examine the influence of narrowband ultraviolet (NB-UVB) therapy on the serum concentration of soluble tumor necrosis factor receptor type 1 (sTNF-R1) in psoriasis patients.

METHODS:

Twenty-seven patients received NB-UVB therapy three to five times a week for 4 weeks. The assessment of skin lesions using psoriasis area and severity index (PASI) and serum concentration of sTNF-R1 was performed at the baseline, at 2, 4 and 4 weeks after treatment cessation. The sera of healthy subject were used as controls.

RESULTS:

The baseline PASI was 13.56 +/- 5.71, sTNF-R1 concentration was 1.89 +/- 0.43 ng/ml in patients and 1.48 +/- 0.30 ng/ml in controls (P < 0.05). The baseline PASI correlated to sTNF-R1 (r = 0.52, P < 0.05). The decline in concentrations of sTNF-R1 paralleled the decline of PASI achieved during therapy but still exceeded control values.

CONCLUSION:

The results of the study confirm the role of sTNF-R1 as a marker of psoriasis severity and efficacy of treatment. They also suggest that NB-UVB influences the serum level of sTNF-R1.

Serwin AB1, Sokolowska M, Chodynicka B.

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