Comparison of the efficacy of calcipotriol and maxacalcitol in combination with narrow-band ultraviolet B therapy for the treatment of psoriasis vulgaris.

Type:Uv phototherapy Time:2015-01-07 17:03:43

Combination treatment with topical vitamin D(3) and narrow-band ultraviolet B (UVB) radiation is effective against

psoriasis vulgaris. We compared the efficacy of the topical vitamin D(3) derivatives calcipotriol and maxacalcitol in combination therapy.

MATERIALS AND METHODS:

In this retrospective observational study, 21 patients admitted to Nagoya City University Hospital between April 2001 and September 2004 were enrolled.

RESULTS:

Combination treatment with calcipotriol or maxacalcitol and narrow-band UVB was effective against psoriasis vulgaris.

Calcipotriol induced a more rapid improvement and required lower levels of narrow-band UVB irradiation to be

effective. Serum calcium levels were slightly increased after 4 weeks of treatment, but there was no significant

difference between the two groups. No other adverse effects were observed in either of the two groups.

CONCLUSION:

The findings of this retrospective observational study indicated that combination treatment with topical vitamin D(3)

derivatives and narrow-band UVB is effective against psoriasis without any obvious side-effects. These findings

provide further evidence that calcipotriol has advantages over maxacalcitol regarding the narrow-band UVB-accumulated

treatment dose and improvement rate of psoriasis area and severity index (PASI) scores.

Noborio R1, Kobayashi K, Shintani Y, Morita A

www.kerneluvb.com----The leader manufacturer of UV Phototherapy.