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PUVA therapy and narrowband UVB therapy in Tunisian patients with mycosis fungoides.

BACKGROUND:

PUVA therapy and narrowband UVB therapy (NBUVB) constitute a widely used first line therapy in mycosis fungoides (MF).

METHODS:

It is a retrospective study dealing with 7 patients with MF treated by phototherapy [3 with PUVA (III, IV, V phototype) and 4 with NBUVB (III-IV phototype)]. One patient had both treatments (PUVA then NBUVB for a relapse).

RESULTS:

Complete response (CR) was achieved in 2 of the 3 patients treated with PUVA (they had stage IB-MF). Both had relapsed after 40 sessions and 7 months later, respectively. Relapses were treated by PUVA maintenance treatment (2 sessions/2 weeks) and NBUVB leading to CR. The third patient (stage IIA) did not respond to PUVA. CR was obtained in the 5 patients treated with NBUVB (stage IA-IB), after a mean cumulative dose of 58.3 J/cm(2). No relapse was noted with NBUVB after a mean follow-up period of 13.2 months (extremes: 2 -31 months).

CONCLUSION:

NBUVB is only effective on non-infiltrated plaques independently of phototype. PUVA therapy is effective even on infiltrated plaques. Both treatments do not prevent relapses.

Khaled A1, Fazaa B, Goucha S, Zeglaoui F, Kamoun MR.

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