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uvb Phototherapy of mycosis fungoides.

Trautinger F.

Author information

Abstract

BACKGROUND/PURPOSE:

Among the primary cutaneous T-cell lymphomas, mycosis fungoides (MF) is the most common disease entity. Recently, an improved 

understanding of the pathology, clinical presentation, and prognosis of MF has lead to the development of new and practically 

useful classification and staging systems. In most patients, MF presents with patches and plaques and remains confined to the 

skin for years and decades, making it an ideal target for UVB phototherapy. However, treatment schedules vary widely and this 

review describes the current knowledge about phototherapy of MF focusing mainly on narrow- and broadband UVB and 8-

methoxypsoralen plus UVA, its indications, practical aspects, and clinical outcome.

METHODS:

Review and summary of the pertinent literature.

RESULTS AND CONCLUSIONS:

Since 1976, when the first report on phototherapy for MF was published, sufficient evidence has accumulated to make 

narrowband UVB and PUVA safe and effective treatment options for early stages of the disease. In refractory cases or more 

advanced stages, combination of phototherapy with systemic treatments including mainly interferons and retinoids might be 

valuable. Additional research is required to further define the optimal treatment schedules and the role of maintenance.

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