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Effect of narrow-band ultraviolet B(UVB)phototherapy on p63 and microRNA (miR-21 and miR-125b) expression in psoriatic epidermis
Type:Uv phototherapy Time:2014-12-11 15:25:01Effect of narrow-band ultraviolet B(UVB)phototherapy on p63 and microRNA (miR-21 and miR-125b) expression in psoriatic
epidermis.
Gu X1, Nylander E, Coates PJ, Nylander K.
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Abstract
Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family that is crucial for skin
development and maintenance, has been demonstrated. Involvement of miR-203, miR-21 and miR-125b, small non-coding RNAs
implicated in the regulation of p63 or p53, has been suggested in the patho-genesis of psoriasis. To elucidate the roles of
p63 and p63-related microRNAs in psoriasis and to increase our understanding of the mechanisms of narrow-band ultraviolet B
(NB-UVB) phototherapy, we studied the effects of NB-UVB treatment on the expression of these molecules. Skin biopsies from 12
psoriasis patients were collected before, during and after NB-UVB therapy. Real-time PCR and immunohistochemistry showed that
p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression of miR-21 (p =
0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated
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