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Effect of narrow band ultraviolet B on survivin in psoriatic skin lesions.

Nagui NA1, Abdel Hay RM, Rashed LA.

Author information

Abstract

BACKGROUND:

Suppression of apoptosis is responsible for epidermal thickness in psoriasis. Survivin is an anti-apoptotic protein that can be modulated by ultraviolet B (UVB).

AIM:

Our aim was to investigate the role of survivin in psoriasis and to evaluate the effect of narrow band (NB)-UVB on the survivin levels in psoriatic lesions.

METHODS:

This study included 20 psoriatic patients and 20 healthy controls. Patients were treated with 24 sessions of NB-UVB. Skin biopsies were taken from the affected skin of each patient before and after treatment, and from the controls, to examine survivin levels by ELISA.

RESULTS:

Survivin was significantly upregulated in psoriasis compared to controls (p<0.001). We found significant positive correlations between survivin levels before therapy and the extent of body involvement (r=0.675, p=0.002), as well as the PASI score (r=0.67, p=0.001). A significant decrease in survivin levels was observed post treatment compared to baseline levels (p<0.001).

CONCLUSION:

We found increased survivin levels in psoriasis and a significant reduction following NB-UVB induced clinical improvement of psoriasis.

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