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Efficacy of narrowband ultraviolet B twice weekly for hypopigmented mycosis fungoides in Asians.

Kanokrungsee S1, Rajatanavin N, Rutnin S, Vachiramon V.

Author information

Abstract

Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma. To date, there have been no data 

published about the efficacy of a twice-weekly regimen of narrowband ultraviolet B (NB-UVB) for the treatment of 

hypopigmented MF. We retrospectively reviewed 11 patients with hypopigmented MF who were treated with NB-UVB twice weekly 

between 2001 and 2010. Of the 11 patients, 7 achieved a complete response with a mean of 40 treatments; the remaining 4 

patients had a partial response. Upon discontinuation of treatment, three patients had clinical relapse after complete 

remission. Median time to relapse was 10 months. A twice-weekly regimen of NB-UVB is an effective treatment for hypopigmented 

MF with minimal side-effects. However, the relapse rate is high, and unfortunately, no clinical or histological features can 

predict the relapse of the disease.

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