Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo: a randomized controlled trial.

Type:Uv phototherapy   Time:2014-12-04 15:56:51
Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of 

vitiligo: a randomized controlled trial.
Verhaeghe E1, Lodewick E, van Geel N, Lambert J.
Author information
Abstract
BACKGROUND:
Limited data are available about the use of 308-nm monochromatic excimer light (MEL) and localized 311-nm narrow-band 

ultraviolet B (NB-UVB) in the treatment of vitiligo. The aim of this study was to evaluate the efficacy of 308-nm MEL versus 

localized 311-nm NB-UVB in vitiligo patients.
METHODS:
Eleven patients participated in this prospective intrapatient placebo-controlled randomized trial. In each patient, 3 lesions 

were selected and treated with NB-UVB, MEL and placebo during 24 sessions, respectively. Repigmentation was evaluated 

clinically and by objective surface measurement.
RESULTS:
Twenty percent of the lesions treated with NB-UVB achieved repigmentation scores above 50%. None of the lesions treated with 

MEL achieved a repigmentation higher than 50% after 24 sessions.
CONCLUSION:
Localized 311-nm NB-UVB is effective in the treatment of vitiligo. It should be considered for localized vitiligo as it is 

easily accessible. In this study the efficacy of localized 311-nm NB-UVB was superior to 308-nm MEL.
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