Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration.

Type:Uv phototherapy   Time:2014-12-03 15:37:40
Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration.
Ala-Houhala MJ1, Vähävihu K, Hasan T, Kautiainen H, Ylianttila L, Viljakainen HT, Snellman E, Reunala T.
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Abstract
BACKGROUND:
A short course of narrowband ultraviolet B (NB-UVB) exposures increases the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients with psoriasis and healthy subjects.
OBJECTIVES:
To compare the effects of NB-UVB and oral vitamin D substitution in healthy subjects in winter.
METHODS:
Healthy adult hospital employees and medical students were screened for serum 25(OH)D concentration. Those with 25(OH)D below 75 nmol L(-1) were randomly given either 12 NB-UVB exposures or 20 μg of oral cholecalciferol daily for 4 weeks. The NB-UVB exposures were given with a Waldmann UV 7001 cabin and the mean cumulative dose was 48，4 standard erythema doses. Serum 25(OH)D was measured before and after the treatments by radioimmunoassay.
RESULTS:
The baseline serum 25(OH)D concentrations were 52，9 ＼ 10，4 (mean ＼ SD) in the 33 NB-UVB-treated and 53，5 ＼ 12，7 nmol L(-1) in the 30 oral cholecalciferol-treated subjects. The mean increase in serum 25(OH)D was 41，0 nmol L(-1) [95% confidence interval (CI) 34，8-47，2; P < 0，001] in the NB-UVB group and 20，2 nmol L(-1) (95% CI 14，6-26，0; P < 0，001) in the cholecalciferol group. The difference between the two treatments was significant at 2 weeks (P = 0，033) and at 4 weeks (P < 0，001). One month after the treatments the 25(OH)D concentrations had increased further.
CONCLUSIONS:
The present study shows that 12 NB-UVB exposures given during 4 weeks increase serum 25(OH)D concentration significantly more than 20 μg of oral cholecalciferol daily. A short NB-UVB course is an effective way to improve vitamin D balance in winter and the response is still evident 2 months after the course.

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