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Therapeutic modalities for localized psoriasis: 308-nm UVB excimer laser versus nontargeted phototherapy.

Mudigonda T1, Dabade TS, West CE, Feldman SR.

Author information

Abstract

UVB phototherapy is an effective treatment modality for psoriasis. For patients with localized plaque-type lesions, 308-nm 

excimer laser phototherapy offers rapidly delivered, targeted, high UVB doses, while sparing adjacent healthy skin. We aimed 

to compare the advantages and disadvantages of the 308-nm xenon chloride (XeCI) UVB excimer laser with nontargeted broadband 

UVB (BB-UVB), narrowband UVB (NB-UVB), and psoralen plus UVA (PUVA) phototherapies. A PubMed search for studies evaluating 

the efficacy and safety of the laser versus nontargeted phototherapeutic modalities was conducted. Three prospective 

nonrandomized studies compared NB-UVB with excimer laser phototherapy. No head-to-head studies were found for BB-UVB or PUVA 

compared to excimer laser. Both the 308-nm excimer laser and nontargeted phototherapies were found to effectively clear 

localized psoriasis. Although it is proposed that excimer laser exclusively treats diseased skin with better response rates, 

split-body trials revealed no differences. Long-term studies are necessary to compare the effects of high-dose excimer laser 

regimens with nontargeted phototherapies.