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Spectral effects of UVB PHOTOTHERAPY on psoriasis.

Weatherhead SC1, Farr PM, Reynolds NJ.

Author information

Abstract

Ultraviolet B (UVB) is a highly effective, relatively safe, affordable and widely used therapeutic option for moderate 

psoriasis. Several types of UVB lamp are available to treat psoriasis, both broadband and narrowband, allowing a choice of 

spectral emission. However despite years of clinical use, the mechanism of action of UVB in clearing psoriasis remained 

incompletely understood. Moreover, there has been little insight into how the relative effectiveness of different UVB 

wavelengths linked to the mechanism of action, although it is known that the action spectrum for clearance of psoriasis 

differs from the action spectrum of erythema. This paper examines the existing literature from which our current treatments 

have evolved, and offers new insight into the use of keratinocyte apoptosis as a biomarker which may help to optimise UV 

treatment in the future. When combined with a systems biology approach, this potential biomarker may provide insight into 

which wavelengths of UV are the most effective in clearing psoriasis, allowing a more rational and potentially an 

individually tailored approach to optimising phototherapy for psoriasis.

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