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Evaluation of histopathological changes in control biopsies which taken 48 sessions after NBUVB phototherapy for early-stage mycosis fungoides.
Type:Uv phototherapy Time:2014-11-26 15:23:53Evaluation of histopathological changes in control biopsies which taken 48 sessions after NBUVB phototherapy for early-stage
mycosis fungoides.
Zemheri E1, Ozkanli S, Zindanci I, Senol S, Akbulak O, Turfanda E, Toprak M, Kosemetin D, Aydin A.
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Abstract
BACKGROUND:
There are not many studies investigating histomorphological changes in 48 sessions in patients with early-stage MF after
narrowband UVB (NBUVB) treatment. Our purpose is to evaluate histological features of phototherapy after 48 sessions and
determine which parameters are more reliable for controlling skin biopsies.
METHODS:
Biopsies of 32 patients with early stage of MF, who were treated with NBUVB phototherapy, were histologically evaluated
before and after the treatments, including epidermotropism, stratum corneum, epidermal thickness, dermal infiltration,
papillary dermal fibrosis, vascular alterations, and other dermal changes. We discuss the histomorphological effects of NBUVB
phototherapy on skin biopsies by comparing the responders with nonresponders, with before and after the treatment.
RESULTS:
9 patients (28%) did not give any response to treatment. Alleviation in epidermotropism, increases in parakeratosis and
normal keratosis, perivascular infiltration, and melanophages, decrease in the lichenoid/patchy lichenoid infiltration
pattern after the treatment was statistically significant. Comparing by response, normalization of stratum corneum and
epidermis, orthohyperkeratosis, decrease in linearly arranged cells, the lichenoid/patchy lichenoid infiltration, the loss of
inflammation were statistically significant in responders group.
CONCLUSION:
We detected a significant decrease in linearly arranged cells after phototherapy, indicating that it is an "important
diagnostic parameter" in evaluation of therapeutic response.
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