Narrow-band UVB (NB-UVB) phototherapy

Narrow-spectrum mid-wave ultraviolet light therapy is a new type of ultraviolet therapy developed on the basis of broad-spectrum UVB phototherapy. The wavelength of NB-UVB is 311nm. Due to the single wavelength, many side effects of ultraviolet rays are prevented, and the therapeutic effect is relatively enhanced. This treatment method is advanced and the curative effect is remarkable.

Indications mainly include psoriasis, vitiligo, pityriasis rosea, chronic eczema, pruritus and herpes zoster.

Mechanism of action

The good effect of NB-UVB on psoriasis is to induce T cell apoptosis. The cytotoxicity of NB-UVB is that it is single, able to penetrate the dermis and release more without causing skin burns. energy.

NB-UVB has obvious therapeutic effect on vitiligo, but the mechanism is still unclear. It is speculated that various cytokines including IL-1, tumor necrosis factor, leukotriene and other non-pigmented black which stimulate hair follicle outer root sheath and dopamine-negative Proliferation, melanogenesis, and migration to the pigment-depleted site cause pigment recovery, and the immunosuppressive effect of NB-UVB is also an important cause of migration and proliferation of melanocytes. NB-UVB has an effective rate of more than 75% in the treatment of vitiligo.

Advanced

NB-UVB can significantly inhibit lymphocyte proliferation and significantly reduce IL-2, IL-10 and interferon-7. The down-regulation of these cytokines has an important influence on the occurrence and severity of inflammatory diseases and allergic diseases. In addition, NB-UVB can reduce the activity of NK cells in the skin, reduce the number of Langerhans cells, and change the cytoskeleton and morphology of Langerhans and the loss of surface markers.

Since its inception, NB-UVB has shown very good results in the treatment of psoriasis, vitiligo, pityriasis rosea, atopic dermatitis, herpes zoster, eczema, pruritus and other diseases. The method is convenient to treat and avoids adverse reactions of drugs, and is currently the most respected treatment for treating the above diseases.