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Digital ultraviolet (UV) therapy - a novel therapeutical approach for the targeted treatment of psoriasis vulgaris.

Werfel T1, Holiangu F, Niemann KH, Schmerling O, L��llau F, Zedler A, Sträter HD, Niebuhr M.

Author information

Abstract

BACKGROUND:

8-methoxypsoralen-UV-A (PUVA) and narrowband UV-B (NB-UVB) are well established treatments for chronic plaque type psoriasis vulgaris. However, long term risks of PUVA therapy are premature skin ageing and squamous cell cancer.

OBJECTIVES:

To develop a device for targeted ultraviolet (UV) therapy of psoriatic plaques with protection of the healthy adjacent skin to reduce the risk for premature skin ageing and squamous cell cancer.

METHODS:

28 patients with exacerbated psoriasis vulgaris were treated with the Digital Phototherapy Device skintrek® [skintrek® cream PUVA (n=8), skintrek® bath PUVA (n=11) and skintrek® UV-B (n=9)] or with conventional bath PUVA (n=9) and NB-UVB (n=4), respectively.

RESULTS:

The local PASI score was significantly reduced from a mean of 6.25 at baseline to 2.75 at the end of therapy in the skintrek® cream PUVA group, from a mean 6.4 to 3.0 in the skintrek® bath PUVA group and from 5.5 to 2.0 in the skintrek® UV-B group. Skintrek® cream PUVA reduced the mean local PASI by 54% while skintrek® bath PUVA did so by 51% and skintrek® UV-B by 63%. Targeted skintrek® PUVA and skintrek® UV-B of inflamed psoriatic skin avoided skin pigmentation and were not inferior to conventional bath PUVA and NB-UV-B therapy regimes.

CONCLUSIONS:

Targeted UV-therapy of psoriatic plaques with the Digital Phototherapy Device skintrek® is as effective as conventional cream and bath PUVA as well as NB-UVB by simultaneously sparing the healthy adjacent skin and therefore (i) potentially reducing the carcinogenic risk, (ii) reducing premature skin ageing and (iii) avoiding tanning of healthy surroundings. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

KEYWORDS:

Psoriasis vulgaris; digital; skin cancer; skintrek®; ultraviolet therapy

www.kerneluvb.com----The leader manufacturer of UV Phototherapy.