Inhibition of HLA-DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment.

Type:Uv phototherapy   Time:2017-12-22 10:33:15
Inhibition of HLA-DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment.
Treatment of human peripheral blood mononuclear cells with UVB light, the photosensitizing system 8-methoxypsoralen plus UVA light (PUVA), or hematoporphyrin derivative plus visible light leads to an inhibition of their stimulatory capacity in an allogeneic mixed leukocyte reaction despite unaltered expression of HLA-DR antigens when tested immediately after irradiation. However, HLA-DR positive cells disappear among mononuclear cells in the interval between 4 and 8 h after treatment with either UVB, PUVA,hematoporphyrin derivative and light, or heating to 45 degrees C. The expression of HLA-DQ, but not HLA-A,B,C, antigens, was similarly affected by these treatments. The significance of these results is discussed.
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