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PUVA therapy: long-term degenerative effects. II. Study of ultrastructural changes in the skin induced by PUVA therapy
Type:Uv phototherapy Time:2017-12-14 9:40:02PUVA therapy: long-term degenerative effects. II. Study of ultrastructural changes in the skin induced by PUVA
therapy
Torras H1, Bombi JA.
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Abstract
The authors studied PUVA induced ultrastructural alterations in a group of 7 patients compared with 6 control
subjects of same age. Hyperactivity of melanocytes was observed in all patients. Elastic fibers showed
vacuolisation age and dose related. There was a reduplication of the basal layer of dermal capillaries and
increased pinocytosis of endothelial cells, age and dose related also. The authors conclude that PUVA therapy
induced alterations are degenerative; the target is located in deep dermis (capillaries and elastic fibers). No
alterations of keratinocytes nor precancerous epithelial dysplasia was found. This confirms that UVA radiation is
less aggressive for keratinocytes than UVB.
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