Polymorphous light eruption.

Type:Uv phototherapy Time:2017-12-14 9:39:43

Hölzle E, Plewig G, von Kries R, Lehmann P.

Abstract

Polymorphous light eruption (PLE) is a common photodermatosis of unknown etiology. It afflicts mainly fair-skinned

patients, with a preponderance of young females. There is, however, no absolute restriction as to age, sex, or

race. Clinical variants include the papular, vesiculo-bullous, and hemorrhagic variety, as well as plaque, erythema

multiforme-like, and insect bite (strophulus)-like types. Skin lesions appear only in certain exposed areas hours

or a few days after intense sunshine, and are nearly always monomorphous in the same patient. The rash subsides

spontaneously within several days without leaving scars. The histopathologic picture is characteristic and shows a

perivascular lymphocytic infiltrate in the upper and middle corium with subepidermal edema, vacuolization of basal

cells, and spongiosis in the lower epidermis. The most important differential diagnoses are solar urticaria,

photosensitive erythema multiforme, and lupus erythematosus. The action spectrum of PLE is under debate.

Reproduction of skin lesions has been reported with UVB, UVA, and, rarely, visible light, with UVA probably being

the most effective part of the spectrum. More important than treatment of PLE is prophylaxis. UVA- and UVB-

effective sunscreens are of some help. Phototherapy and especially photochemotherapy (psoralen + UVA; PUVA) offer

effective ways to decrease light sensitivity. Systemic treatment with chloroquine or beta-carotene has been

disappointing.

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