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Prolongation of murine skin allograft survival by the systemic effects of 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA).
Type:Uv phototherapy Time:2017-12-14 9:36:52Prolongation of murine skin allograft survival by the systemic effects of 8-methoxypsoralen and long-wave
ultraviolet radiation (PUVA).
Granstein RD, Smith L, Parrish JA.
Abstract
Systemic administration of the photoactive drug 8-methoxypsoralen to a group of mice bearing cutaneous allografts,
followed by exposure to long-wave ultraviolet radiation (UVA, 320-400 nm) (PUVA) daily for 14 days at a site
distant from the allograft, significantly increased the survival time of the allografts. This effect was seen both
in donor-recipient combinations that differ at the major histocompatibility complex and in those differing only at
minor histocompatibility loci. Treatment with 8-methoxypsoralen or long-wave UV radiation alone was ineffective in
prolonging allograft survival, as were doses of mid-wave UV radiation (UVB, 280-320 nm) that produced greater
inflammation than the PUVA protocol. Allografted, PUVA-treated animals also demonstrated decreased alloantigen
reactivity against donor-strain spleen cells during the period of treatment by cytotoxicity assays. Allografts of
skin in the murine system are highly immunogenic and are generally rejected faster than organ allografts; thus PUVA
treatment appears to exert a potent effect on prolonging allograft survival. The systemic nature of the effect and
the fact that adverse side effects from PUVA are largely limited to the skin suggest that PUVA might have a role in
clinical organ transplantation management.
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