Polymorphonuclear leucocyte chemotaxis in response to leukotriene B4 in treated and untreated psoriatics.

Type:Uv phototherapy Time:2017-12-14 9:36:11

Various chemoattractants have been implicated in the aetiology of the polymorphonuclear leucocyte (PMN) migration

into the epidermis seen in early lesions of psoriasis. Using an under-agarose technique, the in vitro chemotactic

responses of PMN to the arachidonic acid lipoxygenase product leukotriene B4 (LTB4) were assayed in five groups of

subjects: normal healthy volunteers (n = 12), untreated psoriatics (n = 11) and psoriatics treated with topical tar

(n = 12), PUVA (n = 11) and UVB phototherapy (n = 10). No significant difference was observed between the responses

of control subjects and of untreated psoriatics, nor between the untreated psoriatic group and the PUVA- and UVB-

treated groups, respectively. However, comparison of the tar-treated and untreated groups revealed a significantly

increased chemotactic response to LTB4 in the tar-treated group (p less than 0.01).

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