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Effects of butylated hydroxyanisole on ornithine decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin.
Type:Uv phototherapy Time:2017-11-22 10:07:31Effects of butylated hydroxyanisole on ornithine decarboxylase activity induced by ultraviolet-B and PUVA in mouse
skin.
The effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine
decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet-B
(UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 mumol), PUVA-induced ODC activity
was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB-induced
ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by
different pathways.
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