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Effect of UVB and AS101 on interleukin-2 production and helper activity in psoriatic patients.

Peripheral blood lymphocytes were obtained from eight untreated patients suffering from long-standing plaque-type 

psoriasis 1 h following UVB treatment and at the end of 15 UVB treatments. Before treatment and following in vivo 

treatment with 0.01-0.3 J/cm2, the patients' lymphocytes were tested for interleukin-2 (IL-2) production, and helper activity with and without addition of the immunomodulator AS101. AS101 is a synthetic organotellurium compound, ammonium trichloro-(O,O'-dioxyethylene) tellurate. UVB at a flow of 0.01 J/cm2 did not affect any of these functions. 

However, after 15 UVB treatments, when the dose given had reached 0.3 J/cm2, a complete inhibition of IL-2 production and helper activity was observed. In vitro addition of AS101 at 0.1 micrograms/ml to the in vivo UVB-treated lymphocytes raised IL-2 production to approximately double the initial level, and improved the helper activity of CD4 cells.

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