Efficacy of ultraviolet B phototherapy for psoriasis in patients infected with human immunodeficiency virus.

Type:Uv phototherapy Time:2017-11-08 10:28:00

To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with

human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control

individuals. All patients were evaluated prior to treatment (baseline) and after 21 treatments for the extent of total

body surface area (TBSA) involvement and the quantification of scale, erythema, and thickness of plaques using a scale

of 0 (absent) to 4 (severe). The only concomitant medication allowed was salicylic acid in petrolatum. The cumulative

score for scale, erythema, and thickness improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV group

and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of TBSA involvement in the former and 38.4 +/- 7.6%

reduction in the latter group. None of the differences was statistically significant. There was no statistically

significant difference in the response to therapy among various stages of immunosuppression in the HIV group. There

was also no deterioration of immune status in this group. UVB phototherapy is an effective treatment for psoriasis in

patients infected with HIV. The response is identical to that of matched control individuals.

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