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Serum alpha 2-macroglobulin levels in psoriatic patients treated with UVB and PUVA.

Abnormalities in proteinase metabolisms have been found in psoriasis and higher concentrations of neutral proteinases 

in psoriatic skin lesions than in unaffected skin of psoriatic patients have been observed.

AIM:

The aim of the study was to determine whether repeated whole body UV-(UVB and PUVA) irradiation is associated with 

changes in proteinase inhibitor alpha 2-macroglobulin (alpha 2-M) in patients with active plaque psoriasis.

PATIENTS AND METHODS:

In this study, the sera alpha 2-M levels were evaluated in cases of active plaque psoriasis before UV-, four weeks UVB 

(15 patients) and PUVA (11 patients) irradiation, and two weeks after completed treatment.

RESULTS:

Both UVB and PUVA treatment had no significant influence on alpha 2-M levels in psoriatic sera, it was, however, 

sufficient to treat most of the skin lesions.

DISCUSSION:

The beneficial effect of phototherapy in psoriasis seems not to be mediated through increased binding of proteinases 

by proteinases inhibitor alpha 2-M from serum.