Induction of Darier-White disease with UVB radiation in a clinically photo-insensitive patient.

Type:Uv phototherapy   Time:2017-11-07 17:01:02
Induction of Darier-White disease with UVB radiation in a clinically photo-insensitive patient.
Combination UVA/UVB radiation and UVB radiation alone have been shown to induce the lesions of Darier-White disease. 
However, 6% of patients with Darier-White disease claim that sunlight ameliorates their condition. We performed an 
unblinded, side-by-side controlled trial of UVB, UVA, and combination UVB/UVA phototherapy in a patient with 
historically photoameliorated Darier-White disease to determine whether phototherapy was beneficial, to determine 
whether phototherapy-related heat was detrimental, and to confirm, with appropriate controls, the action spectrum of 
the disease. Phototherapy with radiation in the UVB but not UVA spectrum evoked Darier-White disease in this patient, 
both clinically and histologically. UVB radiation was capable of inducing Darier-White disease in vivo in spite of a 
history of photoamelioration, whereas UVA radiation alone and the heat associated with phototherapy in our protocol 
had no effect on the disease.
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