Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.

Type:Uv phototherapy   Time:2017-11-01 11:22:20
Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB 
exposure: a case study on 33 patients.
Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical 
application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the 
majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the 
group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No 
recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a 
recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to 
defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. 
In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a 
pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.
Comment in
Vitiligo--a window in the darkness.
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