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Narrow-Band Ultraviolet B versus Oral Minocycline in Treatment of Unstable Vitiligo: A Prospective Comparative Trial.
Type:Uv phototherapy Time:2014-11-19 10:44:44Narrow-Band Ultraviolet B versus Oral Minocycline in Treatment of Unstable Vitiligo: A Prospective Comparative Trial.
Siadat AH1, Zeinali N1, Iraji F1, Abtahi-Naeini B2, Nilforoushzadeh MA3, Jamshidi K1, Khosravani P1.
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Abstract
Background. We have compared NB-UVB and oral minocycline in stabilizing vitiligo for the first time. Subjects and Methods. 42
patients were divided equally into two groups: the NB-UVB and minocycline groups. Phototherapy was administered twice a week
on nonconsecutive days. In the minocycline group, patients were advised to take minocycline 100 mg once daily. The treatment
period was 3 months. Vitiligo disease activity (VIDA) score was noted every 4 weeks for 12 months. Digital photographs were
taken at baseline and monthly intervals. Results. Before the therapy, disease activity was present in 100% of the patients,
which was reduced to 23.8% and 66.1% by the end of therapy in the NB-UVB and minocycline groups retrospectively (P < 0.05).
16 of the 21 (76/1%) patients with unstable disease in the NB-UVB group achieved stability, whereas this was the case for
only 7 of the 21 (33.3%) in the minocycline group (P < 0.001). The diameter changes were statistically significant at the end
of treatment in the NB-UVB group compared to the minocycline group (P = 0.031). Side effects in both groups were mild.
Conclusion. NB-UVB was statistically more advantageous than oral minocycline in unstable vitiligo in terms of efficacy and
the resulting stability.
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