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Tazarotene in combination with UVB phototherapy.

Koo JY1.

Author information

Abstract

Despite the vast array of available therapies for treating psoriasis, there remains a need for safer, more effective 

treatments. Topical tazarotene has been shown to be effective in treating mild-to-moderate psoriasis without causing 

the adverse effects, such as mucocutaneous toxicity, hyperostosis, and elevation in serum lipids, often associated 

with orally administered retinoids. A 2-week pretreatment with tazarotene 0.1% gel once daily, followed by tazarotene 

plus UVB therapy (tazarotene-UVB) 3 times per week for 10 weeks, was more effective than UVB therapy alone or in 

combination with vehicle gel in reducing plaque elevation, scaling, and erythema. The tazarotene-UVB treatment was 

well tolerated, and no phototoxicity was observed. Treatment success, defined as a moderate response or better in 

psoriatic lesions (ie, > or = 50% improvement in psoriatic lesions compared with baseline), was achieved within 32 

Days with the tazarotene-UVB treatment, compared with 67 days with UVB alone or UVB plus vehicle gel.

www.kerneluvb.com----The leader manufacturer of UVB Phototherapy.