A randomized comparison of narrow-band TL-01 phototherapy and PUVA photochemotherapy for psoriasis.

Type:Uv phototherapy Time:2017-10-18 10:59:43

BACKGROUND:

Although PUVA treatment of psoriasis is more effective than conventional or broad-band UVB phototherapy, two small

studies have suggested that narrow-band or TL-01 phototherapy may have a therapeutic effect equal to PUVA. If

confirmed, this would be of considerable importance as TL-01 therapy is likely to be considerably safer in the long

term than PUVA.

OBJECTIVE:

The purpose of this study was to compare PUVA with narrow-band (TL-01) phototherapy in psoriasis.

METHODS:

We studied 100 patients with plaque-type psoriasis who were randomly allocated to twice-weekly treatment with PUVA or

narrow-band UVB.

RESULTS:

Clearance of psoriasis was achieved in a significantly greater proportion of patients treated with PUVA (84%) than

with TL-01 (63%) (P =.018), and with significantly fewer treatments (median number of treatments for clearance with

PUVA, 16.7; with TL-01, 25.3; P =.001). Only 12% of those treated with TL-01 were clear of psoriasis 6 months after

finishing treatment compared with 35% for PUVA (P =.002).

CONCLUSION:

When given twice weekly, PUVA is more effective for psoriasis than narrow-band UVB phototherapy.

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