Hypopigmented mycosis fungoides:UVB treatment and a 6(1/2)-year follow-up of 9 patients.

Type:Uv phototherapy Time:2017-10-13 16:37:07

BACKGROUND:

The clinical course of hypopigmented mycosis fungoides has not been well described.

OBJECTIVE AND METHODS:

We sought to review the management and follow-up of patients with hypopigmented mycosis fungoides evaluated between

January 1990 and August 1998.

RESULTS:

There were 7 African American and 2 Asian patients (5 male and 4 female patients); 8 had stage Ia and 1 had stage Ib

disease. The mean age at diagnosis was 34.4 years, the mean latent period was 9.2 years, and the mean follow-up period

after diagnosis was 6.5 years. Treatment modalities used included psoralen UVA, UVB, and topical mechlorethamine.

Eight had complete clinical responses, and another had a partial response. The remission period ranged from 2 months

to 3 years. In all but one patient, lesions recurred; all responded rapidly to another course of therapy.

CONCLUSION:

Hypopigmented mycosis fungoides is characterized by early onset, occurrence in dark-skinned individuals, and good

response to therapy. Recurrences are common. In most, it has a biologically benign course.

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