Optimized UVB treatment of psoriasis: a controlled, left-right comparison trial.

Type:Uv phototherapy Time:2017-10-11 10:36:52

In a randomized, controlled, left-right comparison study, 20 patients with chronic plaque psoriasis were treated with

UVB. One side of the body received UVB in a conventional regimen with fixed dose increments, the other side was given

UVB doses according to measurements of skin pigmentation. Skin pigmentation was quantified by the skin reflectance

technique. The relationship between skin pigmentation and sensitivity to UV radiation was used to optimize and

individualize the initial UVB exposure dose. Clinical outcome, initial, final and cumulative UVB doses, time to 50%

reduction in PASI score, and side-effects were compared. The consequence of the optimization of the UVB doses with a

skin reflectance meter was that the initial UVB dose was significantly higher than in the conventional UVB regimen.

PASI scoring demonstrated a more rapid improvement during the first 2 weeks of treatment on the half body receiving

the optimized treatment compared to the other side (P < 0.05). This new technique offers the same therapeutical

advantages and security as a dose regimen guided by minimal erythema dose testing. However, measurement of skin

pigmentation by skin reflectance is a quick method which can be operated easily by nurses.

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