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Clinical efficacy of narrow-band UVB (311 nm) combined with dithranol in psoriasis. An open pilot study.

BACKGROUND:

For UVB, the most effective wavelength in clearing psoriatic lesions was found to be of 313 nm. The efficacy of whole 

body exposure to narrow-band UVB (311 nm) combined with dithranol in psoriasis has not been evaluated to date.

OBJECTIVE:

Evaluation of the clinical efficacy of phototherapy with narrow-band UVB (311 nm) and dithranol for psoriasis by means 

of whole body exposures and analysis of the mean cumulative irradiation dose.

METHODS:

In this open pilot study, 13 patients were treated for 4-5 weeks. Evaluation of the therapeutic efficacy was performed 

by comparing the Psoriasis Area and Severity Index (PASI) scores at baseline and after 4 weeks of treatment. The 

cumulative irradiation dose was also calculated.

RESULTS:

Evaluation of the PASI scores showed a significant overall reduction of psoriatic lesions after 4 weeks of treatment. 

The cumulative irradiation dose was similar or lower to those found for phototherapy with narrow-band UVB alone.

DISCUSSION:

In patients with widespread psoriasis, treatment with narrow-band UVB (311 nm) combined with dithranol is safe and 

effective, allowing reduction of the cumulative irradiation dose.

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