Long-wave UVA offers partial protection against UVB-induced immune suppression in human skin.

Type:Uv phototherapy Time:2017-09-28 9:10:55

Ultraviolet-B (UVB, 280-320 nm) interferes with the generation of cell-mediated immunity to contact allergens applied

epicutaneously on the irradiated site. To investigate whether pretreatment with UVA-1 (340-400 nm) protects against

the UVB-induced immune suppression we sensitized human volunteers with diphenylcyclopropenone (DPCP) on normal buttock

skin (n= 12), on UVB-irradiated buttock skin (n=21), on buttock skin pretreated with UVA-1 (n= 12), and on buttock

skin pretreated with UVA-1 and thereafter irradiated with UVB (n=22). Sensitization on UVB-irradiated skin reduced the

immunization rate to DPCP compared with sensitization on non-irradiated skin (p<0.01) and skin pretreated with UVA-1

(p<0.01). In contrast, the immunization rate in the group of volunteers sensitized on skin pretreated with UVA-1

before UVB irradiation was significantly higher than the immunization rate in the group of volunteers sensitized on

UVB-irradiated skin alone (p<0.05). These results indicate that pretreatment with UVA-1 under certain conditions

offers partial protection against the UVB-induced reduction in the immunization rates to epicutaneous allergens.

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