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Narrowband UVB phototherapy for early-stage mycosis fungoides.

Gathers RC1, Scherschun L, Malick F, Fivenson DP, Lim HW.

Author information

Abstract

BACKGROUND:

Narrowband UVB (NB-UVB) phototherapy has been shown to be effective for the treatment of various dermatoses.

OBJECTIVE:

We evaluated the effect of NB-UVB in the treatment of early stage mycosis fungoides (MF).

METHODS:

The response of 24 patients (12 stage IA, 12 stage IB) with patch stage MF to thrice weekly NB-UVB was assessed. 

Twelve patients had skin phototypes I-III, and 12 had types IV-VI. Seven patients had hypopigmented MF. Mean follow-up 

period was 29.0 weeks.

RESULTS:

Thirteen patients (54.2%) had a complete response (CR), 7 (29.2%) had partial response (PR), and 4 (16.7%) had no 

response. Specimens from a repeat biopsy in 10 patients with CR showed histologic clearing in 9 of them. Upon 

discontinuation of treatment, 4 patients with CR relapsed, with a mean time to relapse of 12.5 weeks.

CONCLUSION:

NB-UVB is a viable, comparably safe, and easily administered alternative in the management of early stage MF.

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