UVB-activated psoralen reduces luminal narrowing after balloon dilation because of inhibition of constrictive remodeling.

Type:Uv phototherapy   Time:2017-09-25 14:32:12
UVB-activated psoralen reduces luminal narrowing after balloon dilation because of inhibition of constrictive 
remodeling.
Perr��e J1, van Leeuwen TG, Velema E, Smeets M, de Kleijn D, Borst C.
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Abstract
In this study we have explored the potential of PUVB (8-MOP + UVB) therapy for the reduction of luminal narrowing 
after arterial injury. In 15 rabbits, balloon dilation of iliac arteries was performed. In 20 arteries, dilation was 
combined with the delivery of pulsed ultraviolet light B (UVB) irradiation with 10 arteries being previously subjected 
to sensitizer infusion. Changes in vessel diameter, proliferation and extracellular matrix protein content at 6 weeks 
were evaluated by means of angiography and histomorphometry-immunohistochemistry. We found that PUVB, applied at the 
time of dilation, induced reduction in late loss (LL) at 6 weeks (percutaneous transluminal angioplasty vs UVB vs 
PUVB: 0.64 +/- 0.15 mm vs 0.61 +/- 0.05 mm vs 0.29 +/- 0.05 mm; p = 0.018). The same holds true for constrictive 
remodeling (0.53 +/- 0.15 mm vs 0.45 +/- 0.06 mm vs 0.15 +/- 0.05 mm; p = 0.016). In the irradiation groups, LL was 
independent of acute gain (AG), as opposed to the control. Collagen content increased significantly after PUVB in 
media and adventitia, without increased cellular proliferation in all vessel layers. Thus, PUVB at the time of 
dilation reduced luminal narrowing at follow-up without effecting proliferation. This effect was independent of AG and 
was associated with increased collagen content in media and adventitia.
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