No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB phototherapy: a first retrospective study.

Type:Uv phototherapy   Time:2017-09-15 10:36:06
No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB 
phototherapy: a first retrospective study.
Phototherapy of skin diseases such as psoriasis is an effective and safe treatment modality. However, increasing the 
risk of skin cancer by phototherapy is a serious concern. An increased skin cancer risk occurs after prolonged 
photochemotherapy (PUVA). In contrast, the role of broadband UVB or narrowband UVB therapy in skin carcinogenesis of 
humans with psoriasis is less clear. Therefore, we investigated the incidence of skin tumours in a total of 195 
psoriasis patients, receiving broadband (n=69) or narrowband (n=126) UVB from 1994 to 2000 with follow-up until 2003. 
Data were raised from the regional interdisciplinary cancer centre of the University of Tuebingen, Germany and 
compared with the tumour incidences given for the German population. In this study, with 80% statistical power to 
detect a 6-7-fold increase in skin cancer with broadband UVB and 83% power to detect a 5-6-fold increase with narrow 
band UVB at p=0.05, only one patient developed skin cancer - an in situ melanoma. The tumour occurred within the same 
year that phototherapy was initiated. Thus, the present study does not provide evidence for an increased skin cancer 
risk for patients treated with either broadband or narrowband UVB phototherapy
Weischer M1, Blum A, Eberhard F, Röcken M, Berneburg M.
www.kerneluvb.com----The leader manufacturer of UV Phototherapy.