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Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis.

Roman�� J1, Caix��s A, Carrascosa JM, Ribera M, Rigla M, Luelmo J.

Author information

Abstract

BACKGROUND:

Previous studies have shown increased prevalence of metabolic syndrome in patients with psoriasis.

OBJECTIVES:

To characterize the anthropometric and metabolic profile of Spanish patients with moderate to severe psoriasis compared with 

controls without psoriasis matched for gender, age and body mass index (BMI), and to evaluate the impact of narrowband 

ultraviolet B (NB-UVB) therapy on patient profiles.

METHODS:

Baseline waist circumference, body fat composition, lipid, carbohydrate and calcium metabolism profile, inflammation markers, 

homocysteine, vitamins D, B(6) and B(12) and folic acid of 50 patients with psoriasis and 50 matched controls were recorded 

then evaluated after NB-UVB in patients with psoriasis and correlated with clinical outcome.

RESULTS:

Despite very similar BMIs, 54% of patients met International Diabetes Foundation criteria for metabolic syndrome compared 

with 42% of controls (P = 0��01); body fat was 29��9% in patients and 28��0% in controls (P = 0��037), correlating with waist 

circumference; while patient atherogenic profiles were less favourable, with higher apolipoprotein B and low density 

lipoprotein cholesterol than controls, and both patients and controls showed insufficient vitamin D serum levels (< 20 ng mL

(-1)). Mean improvement of Psoriasis Area and Severity Index (PASI) after NB-UVB was 78��2%. Ferritin, B(12) and C-reactive 

protein decreased significantly after NB-UVB therapy. Vitamin D levels reached adequate levels after phototherapy; however, 

no relationship with PASI improvement was observed.

CONCLUSIONS:

We characterized inflammatory and atherogenic profiles of Spanish patients with psoriasis compared with matched controls. 

After NB-UVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated 

by enhancement of vitamin D synthesis.

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