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(PUVA) in psoriasis and vitiligo.
Type:Uv phototherapy Time:2016-11-03 9:46:21Photochemotherapy (PUVA) in psoriasis and vitiligo.
Shenoi SD, Prabhu S1.
Author information
Abstract
Phototherapy with photochemotherapy (PUVA) is a well-known and
well-studied modality for the treatment of psoriasis, which involves
systemic or topical administration of chemicals known as psoralens and
administration of ultraviolet light in increasing dosages after
requisite time gap. PUVA is also used in the treatment of widespread
vitiligo with moderately good results, though it is being surpassed by
ultraviolet B (UVB), which is equally or slightly more efficacious with
fewer side effects. PUVA induces repigmentation by varying mechanisms
such as stimulation of melanogenesis, immunomodulation and activation of
growth factors, though the exact mechanism is still speculative. There
are various studies evaluating the efficacy of PUVA in psoriasis as well
as in vitiligo, either alone or in combination with other
immunosuppressants like azathioprine and calcipotriene.
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