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UVA light is not effective for treating psoriasis on its own, and must be combined with Psoralen, to make the skin more sensitive to the UVA light. Psoralen can be taken as a tablet a couple of hours before the UVA treatment, or applied as a gel or cream onto the area to be treated. PUVA is often used to treat moderate to severe psoriasis that has not responded well to topical treatments or UVB therapy, and hand and foot machines are also available to treat pustular psoriasis.

Like UVB treatment, the psoralen and UVA dosage is carefully calculated and administered in a phototherapy unit in a hospital. Again, the treatment involves standing in a light cabinet for a few seconds or minutes, twice a week for up to eight weeks. Because the psoralen makes the body more sensitive to UVA light, people having the treatment with the tablet psoralen will have to wear special UVA-blocking glasses for around 24 hours after treatment, to prevent the formation of cataracts.

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