Narrowband ultraviolet B interferes with gene expression in the peripheral blood T cells of patients with psoriasis

Type:Uv phototherapy   Time:2015-04-09 16:45:51
Narrowband ultraviolet B interferes with gene expression in the peripheral blood T cells of patients with psoriasis.
BACKGROUND:
Psoriasis pathogenesis and development are closely related to abnormal T cell activity. Narrowband ultraviolet B (NB-UVB) treatment markedly improves skin lesions in psoriasis.
OBJECTIVES:
To investigate differential gene expression in psoriasis and to understand the possible mechanisms of NB-UVB therapy for psoriasis.
METHODS:
The mRNA expression profiles and differentially expressed genes from peripheral blood T cells of psoriatic patients before and after NB-UVB treatment were examined using RNA sequencing and validated by real-time reverse-transcription polymerase chain reaction.
RESULTS:
A total of 129 genes were differentially expressed in the peripheral blood T cells of psoriatic patients: 83 genes were downregulated and 46 were upregulated in psoriatic patients compared to those of healthy subjects. These genes were enriched in intracellular membrane-bound organelles, membrane-bound organelles and the nucleus, and are involved in the cell cycle, apoptosis, inflammation and other processes. These changes are reversed in psoriatic patients with good clinical outcomes following NB-UVB treatment.
CONCLUSION:
NB-UVB treatment has beneficial effects on local psoriatic lesions, possibly due to its effect on peripheral blood T cell gene expression
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