Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action.

Type:Uv phototherapy Time:2015-03-31 16:56:29

Gilchrest BA, Rowe JW, Brown RS, Steinman TI, Arndt KA.

Abstract

The beneficial effect of sunburn-spectrum ultraviolet (UVB) phototherapy on uremic pruritus was studied. Seven

patients were treated twice weekly for 4 weeks with UVB to one half of the body and placebo phototherapy to the

other half. All patients noted generalized improvement without localization of benefit to the UVB side, suggesting

a systemic effect of UVB. A comparison of three schedules varying from one to three treatments weekly showed that

the percentage of patients responding was not influenced by frequency of UVB exposure, although patients treated

more intensively improved faster. In three patients, improvement was delayed until 2 weeks after completion of a

course of six treatments over 2 weeks, indicating a delayed onset of benefit in at least some patients. Overall 32

of 38 patients improved after a course of six or eight UVB exposures. Pruritus has recurred in 15 patients after a

mean remission of 3 months. Sixteen patients are known to remain in remission for a mean of at least 10.6 months

after the first or second course of treatment. The present evidence indicates a systemic mechanism of action for

the long-lasting relief of uremic pruritus afforded by UVB phototherapy.

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