Beneficial effect of oral retinoid in psoriatic hyperproliferation. Autoradiographic studies on involved and non involved skin (author's transl)]

Type:Uv phototherapy   Time:2015-03-31 16:55:33
Beneficial effect of oral retinoid in psoriatic hyperproliferation. Autoradiographic studies on involved and non involved skin (author's transl)].
Dierlich E, Orfanos CE, Pullmann H, Steigleder GK.
Abstract
In 16 patients with generalized psoriasis treated with oral retinoid (Ro 10-9359; 1 mg/kg body weight/(day) 

autoradiographic studies were performed before, and 24 h, 48 h, 1 week and 3 weeks after beginning of treatment on 

involved and non involved epidermis. During the first week no significant changes of all cellular parameters were 

found. However, after 3 weeks of continuing medication the increased 3H-thymidine labelling index was markedly 

lowered and the prolonged DNA synthesis time was shortened; whereas, the cell cycle time remained unaffected. The 

findings revealed that oral retinoid has a distinct influence on epidermal cell proliferation towards normalization 

in both involved and non involved epidermis in psoriasis. The time needed for this effect indicates that the drug 

does not directly interfere with the cell cycle. It seems reasonable, therefore, to combine oral retinoids as a 

basic adjuvant drug with other antipsoriatic techniques, such as retinoid + anthralin, retinoid + PUVA, retinoid + 

UVB.
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