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Oral retinoid and UVB radiation: a new, alternative treatment for psoriasis on an out-patient basis.

Orfanos CE, Steigleder GK, Pullmann H, Bloch PH.

Abstract

The combined application of an oral retinoid (Ro 10-9359) and phototherapy with predominantly UVB radiation 

(Selective Ultraviolet Phototherapy=SUP) is a new, highly effective method of treating psoriasis. It has few side 

effects and can be performed on an out-patient basis. With the aid of this combined treatment we achieved good or 

very good improvement in 19 out of 23 patients with generalized psoriasis (=82.6%). The average number of radiation 

sessions required to achieve this was 22.9, and the mean total therapeutic dose (TTD) was 73 J/cm2. In a control 

group of 40 psoriasis patients, who received only radiation therapy, we achieved good or very good results in only 

60% with an average of 26 radiation sessions and 94 J/cm2 TTD. The effect of the oral retinoid and UVB radiation 

therapy is apparently additive, since the retinoid does not increase the sensitivity of the skin to light.

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