• Home
• Products
  • UV Phototherapy
  • Derma 308
  • MED/MPD Tester
• Order
• FAQ
  • UV Phototherapy
  • Viedo
  • Instruction
  • Real stories
• Membership
• Contact
•  
• KERNEL
  • KERNEL Website
  • Colposcope
  • Photodynamic therapy
  • Patient monitor

Photoprotective effect of a psoralen-UVA-induced tan.

Gschnait F, Brenner W, Wolff K.

Abstract

To determine whether a tan produced by 8-MOP and UVA protects from subsequent solar light irradiation, volunteers 

were irradiated with unfiltered Xenon arc light before and 10 days after a 1 week's course of four 8-MOP-UVA 

treatments. Evaluation of the minimal erythema doses and of histological changes before and after 8-MOP-UVA 

treatment revealed that the 8-MOP-UVA induced tan protected against the erythemogenic and cell damaging effects of 

Xenon arc light. Unscheduled repair DNA synthesis, used as a measure for UVB-induced DNA damage and repair, was 

also investigated in skin irradiated with the Xenon arc before and after 8-MOP-UVA induced tanning. Both the number 

of grains per sparse labeled cell and the number of sparse labeled cells per 1000 cells, were found to be 

significantly lower in tanned skin; taking decreased unschedules repair DNA synthesis as a measure for decreased 

DNA-damage, these findings also demonstrate a photoprotective effect of the 8--MOP-UVA induced tan.

www.kerneluvb.com----The leader manufacturer of UVB Phototherapy.