- 2015-04-20 15:34:38 steroids in combination with UVB should be used only during the initial period in order to achieve a more rapid alleviation of symptoms and to avoid the side effects
A study has been carried out to compare the effect of a combination of clobetasol propionate and UVB versus placebo/UVB. No significant reduction in time to healing was observed. However, symptoms aba...
VIEW - 2015-04-20 15:34:05 PGF-MUM excretion after UVB irradiation in psoriatic patients was fairly increased and amounted to near the mean pre-irradiation level in normal subjects
The influence of ultraviolet B (UVB) irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 7 normal male volunteers and 7 male patients with s...
VIEW - 2015-04-17 16:14:11 changes in arachidonic acid metabolism in the skin may be of pathophysiologic importance in UV-induced inflammatory reaction.
This study was conducted to investigate the metabolism of arachidonic acid in the skin of hairless mice exposed to UVA, PUVA, UVB, and UVC irradiation. The main products of arachidonic acid in the epi...
VIEW - 2015-04-17 16:12:30 PUVA treatment may initiate the same sequence of cellular events as does exposure to sunlamp (UVB, 280-320 nm) radiation, leading to preferential activation of the suppressor cell pathway.
Treatment of mice with 8-methoxypsoralen plus longwave UV radiation (UVA, 320-400 nm) decreased their response to contact sensitizers applied subsequently to unirradiated skin. This decreased rea...
VIEW- 2015-04-17 16:12:04 The cost-effectiveness of the regimen in a day care center is comparable to psoralens and ultraviolet A (PUVA) therapy.
hree hundred patients with severe psoriasis were treated with the Goeckerman regimen in two different day care centers. Each patient was personally evaluated and followed by us for a period of 1 year ...
VIEW- 2015-04-17 16:11:39 coal tars combined with suberythemogenic UVB therapy is a practical alternative (to more aggressive UVB therapy without coal tar) which reduces the UVB exposure to the patient.
Recent studies have questioned the therapeutic value of coal tar versus ultraviolet (UV) radiation and their relative necessity in phototherapy for psoriasis. In this investigation, different aspects ...
VIEW- 2015-04-17 16:10:53 Screening for anti-Ro antibodies may be appropriate in psoriatics prior to UVB phototherapy.
We present four patients with coexistent lupus erythematosus (LE) and psoriasis. This is an unusual combination. All four patients had antibodies to Ro, which were absent in twenty-four control psoria...
VIEW- 2015-04-17 16:10:00 PUVA thus seems the treatment of choice only in UVA-mediated PLE, the action spectrum of the disease at least in most cases being easily discovered from certain anamnestic data.
This study was designed in order to prove on a large-scale basis the efficacy of oral photochemotherapy (PUVA) in the prevention of polymorphous light eruption (PLE), to work out indication crite...
VIEW- 2015-04-17 16:09:18 The mechanism behind the attenuating effect of UV radiation on skin hypersensitivity reactions remains unknown, but it probably does not result from a stabilization of the mast cell membrane, as histamine and compound 48/80 induced reactions were suppressed to a similar extent.
A single UVB or PUVA exposure given 4 days prior to skin testing affected skin responses both to contact allergens and to histamine and the histamine liberator, compound 48/80. The delayed contact hyp...
VIEW- 2015-04-17 16:07:18 No malignant transformation was seen but those were for reasons of safety referred to the risk group category and may prove to be at particular risk on future PUVA therapy.
A thorough clinical and microscopical investigation was conducted in patients with severe longstanding psoriasis maintained on long-term photochemotherapy with PUVA. 250 patients were reinvestigated a...
VIEW
- 2015-04-17 16:12:04 The cost-effectiveness of the regimen in a day care center is comparable to psoralens and ultraviolet A (PUVA) therapy.